Table 2.
MiRNAs dysregulated in human obese subjects.
| miRNA | Up/Down Regulation | Condition | Ref. |
|---|---|---|---|
| Let-7f | ↑/↓ | Obesity and T2D | [65] |
| let-7f-5p | ↑/↓ | Obesity: changes after bariatric surgery | [59] |
| let-7-i-5p | ↑/↓ | Obesity: changes after bariatric surgery | [59] |
| miR-7-5p | ↑/↓ | Obesity: changes after bariatric surgery | [59] |
| miR-15a | ↓ | Obesity | [58] |
| miR-15b-5p | ↑/↓ | Obesity: changes after bariatric surgery | [59] |
| miR-16 | ↑/↓ | Obesity | [62] |
| miR-17-5p | ↑/↓ | Associated with BMI, FBG, HbA1c in obesity | [63] |
| miR-20b | ↑ | Obesity and T2D | [64,65] |
| miR-21-5p | ↓ | Obesity | [60] |
| miR-23a-3p | ↓ | Obesity and T2D (negatively correlated with adiposity and IR index) | [66] |
| miR-27 | ↑ | Obesity | [67] |
| miR-28-3p | ↓ | Obesity | [62] |
| miR-29a-3p | ↓ | Obesity | [64] |
| miR-29a-5p | ↓ | Obesity | [64] |
| miR-103-5p | ↓ | Obesity | [60] |
| miR-122 | ↑/↓ | Obesity | [62] |
| miR-125-5p | ↓ | Obesity | [60] |
| miR-125b | ↑/↓ | Obesity | [62] |
| miR-130b | ↑/↓ | Obesity | [58,62] |
| miR-132 | ↑/↓ | Associated with BMI, FBG, HbA1c in obesity | [63] |
| miR-140-5p | ↑/↓ | Obesity | [58,60,62] |
| miR-142-3p | ↑ | Obesity and T2D | [58,60,62] |
| miR-143 | ? | Promotion of lipid accumulation, positively associated with insulin-enhanced lipogenesis and WAT IR in obesity | [70] |
| miR-181a-5p | ↓ | Obesity and T2D (negatively correlated with adiposity and IR index) | [66] |
| miR-195 | ↑/↓ | Obesity | [62] |
| miR-205-5p | ↑/↓ | Obesity: responsive to bariatric surgery | [59] |
| miR-221 | ↑/↓ | Obesity and T2D | [58,62,68] |
| miR-221-3p | ↓ | Obesity | [60] |
| miR-222 | ↑/↓ | Obesity and T2D | [58,60,62] |
| miR-296 | ↑/↓ | Obesity and T2D | [65] |
| miR-320c | ↑/↓ | Obesity: responsive to bariatric surgery | [59] |
| miR-328 | ↑/↓ | Obesity | [62] |
| miR-335-5p | ↑/↓ | Obesity: responsive to bariatric surgery | [59] |
| miR-363 | ↑/↓ | Obesity | [62] |
| miR-374a-5p | ↑ | Metabolic syndrome | [61] |
| miR-423-5p | ↑/↓ | Obesity | [58,62] |
| miR-486 | ↑ | Obesity | [62] |
| miR-519d | ↑ | Obesity: promotes lipid accumulation | [69] |
| miR-520c-3p | ↓ | Obesity | [58] |
| miR-532-5p | ↑/↓ | Obesity | [62] |
| miR-592 | ↓ | Obesity (in liver) | [71] |
| miR-652-3p | ? | Positively associated with insulin-enhanced lipogenesis and WAT IR in obesity | [70] |
| miR-802 | ↑ | Obesity impaired glucose tolerance and reduced insulin sensitivity in liver | [72] |
Abbreviations: ↑ = up-regulated; ↓ = down-regulated; ? = unknown; miRNA = microRNA; T2D = type 2 diabetes; KO = knock-out; FOXO1 = forkhead box O1; BAT = brown adipose tissue; BMI = body mass index; FBG = fasting blood glucose; HbA1c = glycated haemoglobin; WAT = white adipose tissue; IR = insulin resistance.