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. 2019 Jun 21;11(6):868. doi: 10.3390/cancers11060868

Figure 2.

Figure 2

Extracellular vascular endothelial growth factor-A (VEGF-A) levels of Mel-270 und OMM-2.5 cells after a one-day exposure to bevacizumab or ranibizumab as determined by ELISA. Metastatic OMM-2.5 cells secreted significantly more VEGF-A than the corresponding primary tumor cells (Mel-270). Bevacizumab suppressed VEGF-A levels in the supernatant of both cells for a short period (one day). Ranibizumab at a concentration of 250 µg/mL was still able to significantly reduce the amount of VEGF-A in both cell types after three days. * p < 0.05, *** p < 0.001, **** p < 0.0001.