Table 2.

Key targets and role of EV derived non-coding RNAs in colorectal cancer.

micro-RNA/ lncRNA/Proteins	Level	Key Targets	Role in CRC	Reference
miR-17-92a	upregulated	TSP-1, CTGF, PTEN,BCL2L11,E2F1,E2F2, E2F3,TGFBR2,CDKN1A,BIM	Angiogenesis, proliferation, metastasis	[71,72,73]
miR-18a	upregulated	ATM, mTORC1, hnRNP A1,CDC42	Cell proliferation, migration	[71,73,74,75]
miR-92a	upregulated	PTEN	cell proliferation, migration, invasion, prognosis	[76]
miR-218	downregulated	BMI-1	cell proliferation, apoptosis, cell cycle arrest	[77]
miR-31	upregulated	CDKN2B, RASA1,FIH-1, RhoBTB1	Cell proliferation, invasion, migration, tumor growth, prognosis	[73,78,79]
miR-95	upregulated	SNX1	cell proliferation, tumor growth	[80]
miR-29a	upregulated	KLF4	cell invasion, metastasis, prognosis	[81,82]
miR-96	upregulated	TP53INP1, FOXO1, FOX03a	cell proliferation	[83]
miR-214	downregulated	FGFR1	cell proliferation, migration, invasion	[84]
miR-100	downregulated	RAP1B	cell proliferation, invasion, apoptosis	[79]
miR-194	downregulated	PDK1, AKT2, XIAP, MAP4K4	Cell proliferation, apoptosis, migration, prognosis	[79]
miR-206	downregulated	NOTCH3	cell proliferation, migration, apoptosis, cell cycle arrest	[85]
miR-103	upregulated	DICER, PTEN	cell proliferation, migration, tumor growth	[86]
miR-143	upregulated	KRAS, ERK5, MACC1, HK2, IGF1R, DNMT3A	Cell proliferation, metastasis	[73,74]
miR-196b	upregulated	FAS	cell apoptosis	[87]
miR-148a	upregulated	BCL2	Cell proliferation	[73,88]
miR-375	downregulated	PIK3CA	cell proliferation, cell cycle arrest, tumor growth	[89]
miR-181a	upregulated	WIF-1, PTEN	cell proliferation, migration, invasion, prognosis, tumor growth	[90,91]
miR-21	upregulated	PDCD4, CCL20, Cdc25A, TGFBR2, PTEN, RHOB, RASA1	Cell proliferation, migration, invasion, metastasis, stemness	[73,92]
miR-155	upregulated	CLDN1	Cell proliferation, migration, invasion, chemoresistance	[73]
miR-145	downregulated	FASCIN-1	Cell proliferation, invasion, tumor growth	[93]
miR-32	upregulated	PTEN	cell proliferation, migration, invasion, apoptosis	[94]
miR-378	downregulated	VIMENTIN	cell proliferation, invasion, tumor growth, prognosis	[95]
miR-124	downregulated	STAT3	cell proliferation, apoptosis, tumor growth, prognosis	[96]
miR-126	downregulated	VEGF, IRS-1, CXCR4	cell proliferation, migration, invasion, prognosis	[97,98,99,100]
miR-10b	upregulated	Syndecan-1	tumor suppression, invasion	[101]
miR-375	upregulated	Bcl-2	apoptosis, tumor suppression	[102]
miRNA-210	upregulated	VMP1	tumor growth, metastasis, migration, invasion	[103,104]
miR-200c	upregulated	ZEB2 and SNAI, PTEN	migration, metastasis, invasion, tumor growth	[102,105]
miR-141	upregulated	ZEB2 and SNAI, MAP2K4	migration, metastasis, cell proliferation	[102,106]
miR-429	upregulated	ZEB2 and SNAI, HOXA5	migration, metastasis, tumor growth	[102,107]
miRNA-19a	upregulated	TIA1	Cell proliferation and migration	[108,109]
let-7a	upregulated	NIRF	Cell proliferation, tumorigenesis	[108,110]
miR-1246	upregulated	CycG2, CCNG2	differentiation, invasion, metastasis, chemoresistance	[108,111]
miR-150	upregulated	iASPP	tumor growth, metastasis, cell proliferation	[108,112]
miR-21	upregulated	TIMP3, ANP32A, THRB, PELI1, SPRY 1/2, PDCD4, FASL, PTEN, BCL2, PPARA, HNRPK, TP63	Cell proliferation, invasion, metastasis, apoptosis	[108,113]
miR-223	upregulated	STMN-1	cell proliferation, migration, invasion	[108,114,115]
miR-23a	upregulated	MTSS1	migration, metastasis, cell migration, invasion	[108,116]
miR-193a	upregulated	Caprin1	tumor progression	[117]
ΔNp73	upregulated		Cell proliferation, drug resistance	[118]
CRNDE-h	upregulated	DUSP5/CDKN1A	proliferation, apoptosis, metastasis	[119,120]
MAGEA3	upregulated		cell growth, differentiation, invasion	[121,122]