Figure 2.

Determination of anabolic and catabolic biomarkers in cartilage and synovial fluid, respectively, after trauma with and without pharmacologic intervention. Femoral condyle sections of rabbits were immunohistochemically stained for (A) MMP13 and (B) COL2, respectively. The red arrows indicate MMP13-positive cells. The black bar represents 100 µm. Additionally, concentrations of (C) MMP-13 and (D) CPII were determined in the synovial fluid by means of specific ELISA; data values are charted as scattered plots with bars, n = 5. T = trauma + NaCl, T+B = traumatized and BMP7-treated, T+N = traumatized and NAC-treated, T+N+B = traumatized and BMP7- plus NAC-treated.