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. 2019 Jun 18;8(6):610. doi: 10.3390/cells8060610

Figure 3.

Figure 3

Keratin 23 serum levels decrease in response to direct-acting antiviral (DAA)-mediated viral clearance. (A) Keratin expression levels of pre-treatment and post-treatment liver biopsies of chronic hepatitis C patients at indicated time points after PEGylated interferon-α/ribavirin treatment. Raw data were obtained from Boldanova et al. [30]. (B) Heatmap of mRNA expression levels of keratins in primary human hepatocytes (PHHs) upon IFN-α (100 IU/mL), IFN-λ3 independent donors 6 h post-treatment. mRNA. (C) Keratin 23 sera levels of chronic hepatitis C patients (n = 5) pre- and post-DAA therapy. Patient sera, obtained prior to DAA treatment and post-viral clearance were assessed for the keratin 23 content via dot blot analysis. (D) Quantification of keratin 23 signals of the dot blot analysis (C). Keratin 23 level prior to DAA treatment was arbitrarily set as one. Shown are mean values ± standard deviation from five donors (unpaired two-tailed Student’s t-test; * p < 0.05).