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Three out of five patients who developed distant metastasis had CTCs detected before radiographic detection of metastasis. Patients 001, 012, and 018 had CTCs detected 24.9, 9.5 and 3.2 months prior to radiographic evidence of metastasis, respectively. Patient 003 and 029 were “non-secretors” for CTCs as they had no CTC detected pre and post metastasis detection by radiographic imaging.
