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Animal body weight change in mice receiving saline (blue), free paclitaxel and everolimus (PTX+EVER) (green), and dual-targeted PTX+EVER-loaded nanoparticles (Dual-NPs) (red) from the first day of treatment to the ethical endpoint. Data represent mean ± SD (n = 8). Two-way analysis of variance (ANOVA) was conducted where *, **, and * indicate p < 0.04, p = 0.004, and p < 0.0001, respectively.
