Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Parallel artificial membrane permeability blood brain barrier (PAMPA-BBB) data of SP1–6.
| LD | SP1 | SP2 | SP3 | SP4 | SP5 | SP6 | |
|---|---|---|---|---|---|---|---|
| Pe (10−6 cm/s) | 0.75 (±1.67) |
1.15 (±0.12) |
1.82 (±0.18) |
3.1 (±1.3) |
0.94 (±0.05) |
2.3 (±0.83) |
4.5 (±0.88) |
| Classification 1 | CNS− | CNS− | CNS− | CNS+/− | CNS+ | CNS− | CNS+/− |
1 CNS+ (indicative of high BBB permeation): Pe (10−6 cm/s) > 4; CNS+/- (indicative of uncertain BBB permeation): Pe (10−6 cm/s) from 4 to 2; CNS− (indicative of low BBB permeation): Pe (10−6 cm/s) < 2.
