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The α-lobe topology in C3-like toxins. Depiction of the V–L–αα-corner topology of the α- lobe. The green arrows correspond to the inertial axes of the α-helices. The βII sheet is shown in yellow ribbons with β3, β5, and β6 strongly interacting with the elements of the αα corner. The PN (phosphate-nicotinamide) loop is an NAD+ substrate-binding loop and it is indicated along with the N-terminus (N-terminal tail) of the domain.
