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The α-lobe stability. α2–α4 superstructure of C3larvin (PDB: 4TR5), showing three hydrophobic clusters (depicted as green spheres) centered at three key residues. The structural “clusters” for the α2–α4 superstructure are designated as I, II, and III and the superstructure is framed by three α helices (α1, α2, and α3).
