Skip to main content
. 2019 Jun 19;11(6):355. doi: 10.3390/toxins11060355

Table 1.

Characteristics of recombinant toxins of Loxosceles spider venoms.

Toxin Family MM
(kDa)		 Species Biological Characteristics N° of Sequences PDB
PLD 30–35 L. arizonica [45]
L. boneti [36]
L. gaucho [46]
L. intermedia [28]
L. laeta [32]
L. reclusa [34]
L. similis [35] 		-Hydrolysis of phospholipids;
-Transphosphatidylation;
-Dermonecrosis;
-Inflammatory response;
-Lethality;
-Hemolysis;
-Platelet aggregation;
-Edema;
-Nephrotoxicity;
-Cytotoxicity;
-Cytokine activation;
-Complement activation.		 199 1XX1
2F9R
3RLH
3RLG
4RW5
4RW3
Metalloprotease 30 L. intermedia [42] -Hydrolysis of Gelatin, Fibronectin and Fibrinogen;
-Cytotoxicity.		 3 N.A.
ICK peptides 12 L. intermedia [44] -Insecticidal activity. 1 N.A.
Hyaluronidase 45 L. intermedia [6] -Hydrolysis of hyaluronic acid and chondroitin sulfate;
-Dermonecrosis spreading.		 1 N.A.
TCTP 22 L. intermedia [10] -Edema;
-Vascular permeability.		 1 N.A.

N.A: not applied.