Table 2.
Estimated marginal means M (SE) of sleep variables within treatment conditions.
| Placebo |
Tryptophan |
|||||
|---|---|---|---|---|---|---|
| S’/S’ | L’/L’ | Total | S’/S’ | L’/L’ | Total | |
| Sleep diary | ||||||
| Sleep onset latency (min) | 20.11 (2.53) | 17.05 (2.46) | 18.53 (1.76) | 18.78 (2.53) | 15.48 (2.46) | 17.08 (1.76) |
| Nocturnal awakenings | 1.61 (0.13) | 1.36 (0.13) | 1.48 (0.09) | 1.49 (0.13) | 1.54 (0.13) | 1.51 (0.09) |
| Wake after sleep onset (min) | 11.93 (1.69) | 8.83 (1.63) | 10.33 (1.18) | 12.77 (1.69) | 10.44 (1.64) | 11.57 (1.18) |
| Total sleep time (h) | 7.67 (0.11) | 7.58 (0.10) | 7.62 (0.07) | 7.58 (0.11) | 7.66 (0.10) | 7.62 (0.07) |
| Sleep quality | 3.60 (0.07)a,b | 3.90 (0.07)b | 3.75 (0.05) | 3.71 (0.07)a | 3.81 (0.07) | 3.76 (0.05) |
| Refreshed sleep | 3.26 (0.09) | 3.43 (0.88) | 3.35 (0.06) | 3.28 (0.09) | 3.37 (0.88) | 3.24 (0.06) |
| Actigraphy | ||||||
| Sleep onset latency (min) | 6.64 (0.72) | 6.06 (0.70) | 6.34 (0.50) | 6.96 (0.71) | 6.03 (0.69) | 6.48 (0.50) |
| Sleep efficiency (%) | 84.42 (0.75) | 84.97 (0.73) | 84.70 (0.52)c | 85.26 (0.74) | 86.08 (0.73) | 85.68 (0.52)c |
| Total sleep time (h) | 6.78 (0.12) | 6.71 (0.11) | 6.74 (0.08) | 6.76 (0.12) | 6.86 (0.11) | 6.81 (0.08) |
| Wake after sleep onset (min) | 68.06 (3.60) | 65.53 (3.50) | 66.76 (2.50)c | 63.13 (3.57) | 60.09 (3.49) | 61.57 (2.49)c |
| Nocturnal awakenings | 24.34 (0.92) | 23.54 (0.89) | 23.93 (0.64) | 23.69 (0.91) | 23.37 (0.89) | 23.52 (0.64) |
M: mean; SE: standard error.
a
Main effect of treatment in S’/S’ group (p < 0.10).
b
Main effect of 5-HTTLPR in placebo condition (p < 0.01).
c
Main effect of treatment (p < 0.001).