Table 1.
Patient demographics, surgical and catheterization results, presented as mean values and standard deviations, with ranges in brackets as appropriate
| Control n = 44 | BCPC n = 20 | Fontan n = 62 | p value BCPC vs control | p value Fontan vs control | p value Fontan vs BCPC | SLV Fontan n = 34 | SRV Fontan n = 21 | p value SRV vs SLV | |
|---|---|---|---|---|---|---|---|---|---|
| Clinical | |||||||||
| age at CMR (years) | 13.7 ± 2.9 (7.4–17.7) | 2.8 ± 0.9 (0.6–4.5) | 11.4 ± 4.4 (3.6–17.8) | < 0.001* | 0.001* | < 0.001* | 12.2 ± 4.2 | 11.4 ± 4.2 | 0.3 |
| gender, male n (%) | 18 (41%) | 13 (65%) | 36 (58%) | 0.1 | 0.06 | 0.4 | 21 (61%) | 11 (52%) | 0.8 |
| weight (kg) | 59.9 ± 23.3 | 13.3 ± 2.8 | 37.1 ± 17.6 | < 0.001* | < 0.001* | < 0.001* | 41.5 ± 18.5 | 36.3 ± 15.1 | 0.2 |
| BSA (m2) | 1.6 ± 0.38 | 0.6 ± 0.1 | 1.2 ± 0.38 | < 0.001* | < 0.001* | < 0.001* | 1.3 ± 0.4 | 1.2 ± 0.4 | 0.5 |
| systolic BP (percentile) | – | 85.8 ± 23.1 | 60.7 ± 29.3 | – | – | < 0.001 | 58.8 ± 30.2 | 60.6 ± 28.5 | 0.8 |
| diastolic BP (percentile) | – | 81.7 ± 17.8 | 49.2 ± 28.4 | – | – | < 0.001 | 50.3 ± 29.3 | 41.9 ± 23.9 | 0.2 |
| O2 saturation (%) | – | 84 ± 5 | 93 ± 5 | – | – | < 0.001 | 94 ± 5 | 93 ± 5 | 0.6 |
| Surgical | |||||||||
| age at BCPC (years) | – | 0.5 ± 0.2 | 0.6 ± 0.4 | – | – | 0.3 | – | – | |
| age at Fontan (years) | – | – | 3.3 ± 0.9 | – | – | – | 3.2 ± 0.8 | 3.5 ± 1.1 | 0.2 |
| interval MR BCPC/ Fontan op (days) | – | 3895 ± 658 | 2888 ± 1684 | – | – | 0.01 | 3296 ± 1619 | 2856 ± 1628 | 0.3 |
| total CPBT (minutes) | – | 154 ± 98 | 252 ± 108 | – | – | 0.001 | 209 ± 107 | 310 ± 75 | 0.001 |
| total CAT (minutes) | – | 26 ± 9 | 16 ± 15 | – | – | 0.08 | 20.5 ± 23 | 16 ± 14 | 0.7 |
| total CCT (minutes) | – | 62 ± 56 | 82 ± 64 | – | – | 0.2 | 60 ± 66 | 97 ± 42 | 0.03 |
| Catheterization | |||||||||
| interval MR to catheterization (days) | – | 86 ± 183 | 1719 ± 183 | – | – | < 0.001 | 2096 ± 1898 | 1675 ± 726 | 0.4 |
| age at catheterization (years) | – | 2.6 ± 1.2 | 6.7 ± 4.2 | – | – | 6.8 ± 4.7 | 6.9 ± 3.9 | 0.9 | |
| VEDP (mmHg) | – | 7.7 ± 2.1 | 7.2 ± 2.3 | – | – | 0.6 | 8.3 ± 2.3 | 6.3 ± 2.6 | 0.2 |
| CVP (mmHg) | – | 10.7 ± 3.1 | 10.9 ± 0.8 | – | – | 0.6 | 10.3 ± 1.5 | 10.6 ± 1.7 | 0.6 |
| atrial pressure (mmHg) | – | 4.9 ± 2.1 | 5.3 ± 2.1 | – | – | 0.6 | 6.2 ± 2.3 | 5.4 ± 1.1 | 0.5 |
*One way Analysis of variance tested for multiple comparisons with post-hoc Tukey
BCPC bidirectional cavo-pulmonary connection, BSA body surface area, BP blood pressure, CAT circulatory arrest time, CPBT cardiopulmonary bypass time; CCT cross-clamp time, CMR cardiovascular magnetic resonance, CVP central venous pressure, SLV single left ventricle; SRV single right ventricle, VEDP ventricular end-diastolic pressure