. 2019 Jun 25;8(6):634. doi: 10.3390/cells8060634

Table 2.

IL2RA genotype effects on the CD127⁺CD25⁺ population in relation to CD8⁺ T cell differentiation. A risk genotype (TT) is defined as a homozygous carrier of the risk allele (T) for both MS-associated IL2RA SNPs rs2104286 and rs11256593. A protective genotype (CC) is defined as a homozygous carrier of the protective allele (C) for both MS-associated IL2RA SNPs rs2104286 and rs11256593.

Subset *	N_Pair	Median Frequency of CD127⁺CD25⁺ Cells		Wilcoxon Signed Rank Test	Median MFI ** of CD25 on CD127⁺CD25⁺ Cells		Wilcoxon Signed Rank Test
Subset *	N_Pair	CC	TT	Wilcoxon Signed Rank Test	CC	TT	Wilcoxon Signed Rank Test
Naive	23	3.4	2.7	n.s.	728	610	n.s.
T-CM	23	34.3	25.2	0.03	972	866	n.s.
CM	23	34.7	35.8	n.s.	1337	1240	n.s.
EM	23	12.3	11.8	n.s.	1296	1269	n.s.
L-EM	23	9.6	7.7	n.s.	892	827	n.s.
T_EMRA	23	0.9	0.7	n.s.	745	788	n.s.

* Subset abbreviations: T-CM = Transitional central memory; CM = Central memory; EM = Effector memory; L-EM = Late-EM; T_EMRA = Terminally differentiated effector memory. ** MFI = median fluorescence intensity. p value depicting a trend for association is indicated in italics.