Table 4.
Summary of cardiac magnetic resonance imaging parameters (RVEF and LVEF).
| Parameter | Visit | Statistic | Cohort 1 (transitioning from parenteral, n = 10) | Cohort 2 (transitioning from inhaled, n = 10) | Cohort 3 (as add-on to current PAH therapy, n = 12) |
|---|---|---|---|---|---|
| RVEF (%) | Baseline | n | 4 | 9 | 10 |
| Mean (SD) | 50.5 (5.1) | 48.4 (8.6) | 49.1 (4.7) | ||
| Week 24 | n | 4 | 10 | 9 | |
| Mean (SD) | 54.5 (8.1) | 49.0 (4.9) | 48.8 (5.0) | ||
| Change from baseline to week 24 | n | 4 | 9 | 9 | |
| Mean (SD) | 4.0 (7.6) | 0.4 (7.1) | −0.7 (2.7) | ||
| P value* | 0.3707 | 0.8552 | 0.4860 | ||
| LVEF (%) | Baseline | n | 4 | 9 | 10 |
| Mean (SD) | 57.8 (2.2) | 55.7 (5.0) | 59.6 (4.6) | ||
| Week 24 | n | 4 | 10 | 9 | |
| Mean (SD) | 56.8 (2.2) | 57.8 (3.7) | 57.9 (4.3) | ||
| Change from baseline to week 24 | N | 4 | 9 | 9 | |
| Mean (SD) | −1.0 (1.4) | 2.4 (6.0) | −2.4 (3.1) | ||
| P value* | 0.2522 | 0.2581 | 0.0448 |
*
P values were calculated using paired t-test within each cohort.
LVEF, left ventricular ejection fraction; PAH, pulmonary arterial hypertension RVEF, right ventricular ejection fraction, SD, standard deviation.