Table 2.
Incidence and determinants of hepatocellular carcinoma in autoimmune hepatitis.16 Tansel and colleagues recently published a systematic review and meta-analysis of the incidence of HCC and associated risk factors among patients with AIH. A total of 6528 patients were included. Based on the reported HCC incidence rates shown in this meta-analysis, the authors suggest that here may be a role for HCC surveillance in patients with AIH and cirrhosis.
| Study Size | 25 studies (20 papers, 5 abstracts) including 6528 AIH patients (118 with HCC) |
| Cohort | Median size: 170 patients (25–1721) median follow-up: 8.0 years (3.3–16.0) |
| HCC Incidence Rate | AIH patients: 3.1 × 1000 patient/year (2.2–4.2). patients with cirrhosis: 10.1 per 1000 patient-year (6.9–14.7) |
AIH, autoimmune hepatitis; HCC, hepatocellular carcinoma.