Table 3.
Risk factors for cholangiocarcinoma in the USA.35 Of all CCA cases (1169 iCCA, 995 pCCA, and 231 dCCA) seen at the Mayo Clinic from 2000 through 2014, 2395 were enrolled; 4769 subjects matched by age and sex were included as controls.
| Subtypes | Risk factors, OR | ||
|---|---|---|---|
| iCCA 48.8% | 171.2 | PSC | (pCCA>iCCA>dCCA) |
| Perihilar (pCCA) 41.5% | 12.1 | BTD | (iCCA>pCCA) |
| Distal (dCCA) 9.6% | 10.8 | Cirrhosis* | (iCCA>pCCA>dCCA) |
| 2.8 | HBV | (iCCA>pCCA>dCCA) | |
| 2.8 | DTM | (dCCA>pCCA>iCCA) | |
| 1.3 | Smoke | (dCCA>iCCA>pCCA) | |
| 0.34 | Aspirin | (dCCA<pCCA<iCCA) | |
BTD, biliary tract diseases; dCCA, distal cholangiocarcinoma; DTM, Diabetes; iCCA, intrahepatic cholangiocarcinoma; PSC, primary sclerosing cholangitis.
*
Non-PSC related cirrhosis.