Table 2.

All identified protein expression change in paclitaxel-resistant MCF7/PacR cells compared to paclitaxel-sensitive MCF7 cells. The table includes protein name, protein localization within the cell, known or predicted function in the cell, localization of the gene within the human genome, expression level in MCF7/PacR cells (compared to the level in MCF7 cells) determined by western blot, and corresponding references.

Protein Name/Abbreviation	Protein Localization	Function	Gene Localizaton	Expression in MCF7/PacR Cells
ATP binding cassette subfamily B member 1, ABCB1	Plasma membrane	Drug efflux [14]	7q21.12	Overexpressed, concrete level not determined [14]
ATP binding cassette subfamily B member 4, ABCB4	Plasma membrane	Drug efflux [14]	7q21.12	Overexpressed, concrete level not determined [14]
ATP binding cassette subfamily C member 2, ABCC2	Plasma membrane	Drug efflux [14]	10q24.2	Overexpressed, concrete level not determined [14]
ATP binding cassette subfamily C member 3, ABCC3	Plasma membrane	Drug efflux [14]	17q21.33	Overexpressed, concrete level not determined [14]
Abhydrolase domain-containing protein 11, ABHD11	Mitochondria	Putative lipid hydrolase [52]	7q11.23	68% [this paper]
ATPase family AAA domain-containing protein 3A and 3B, ATAD3A, ATAD3B	Mitochondria	Multiple (mitochondrial network, cristae structure, nucleoid binding) [69,71,72,73,74,75]	1p36.33	154% [this paper]
Carbamoyl-phosphate synthetase 1, CPS1	Mitochondria	Enzyme (urea cycle) [59,61]	2q34	494% [this paper]
Cathepsin D, CTSD	Lysosomes	Protein degradation, cell death [40,48,49]	11p15.5	28% [30], 19% [this paper]
Heat shock protein family B (small) member 1, HSP27	Cytosol	Signaling [30]	7q11.23	47% [30]
Thyroid hormone receptor interactor 6, TRIP6	Cytosol	Antiapoptotic signaling [30]	7q22.1	650% [30]