Table 4.
Effect of fosfomycin on different multidrug resistant isolates
| MDR isolates Total N=326 |
MIC of Fosfomycin [µgm/mL] (%) | |||||
|---|---|---|---|---|---|---|
| 16 | 32 | 64 | 128 | 256 | 512 | |
|
Escherichia coli* N=217 |
0 | 0 | 0 | 0 | 0 | 0 |
|
K.pneumoniae# N=52 |
18 (35) | 18 (35) | 18 (35) | 18 (35) | 11 (20) | 6 (12.2) |
|
Pseudomonas sppα N=32 |
16 (50) | 16 (50) | 16 (50) | 16 (50) | 16 (50) | 12 (38.4) |
|
Enterobacter sppδ N=25 |
15 (59.5) | 10 (40) | 10 (40) | 10 (40) | 9 (36) | 9 (36) |
Notes: *For Escherichia coli the MIC of fosfomycin according to CLSI (S 64 µgm/mL, I=128 µgm/mL. R 256 µgm/mL).The MIC 50 and MIC 90 of fosfomycin in Escherichia coli was 1 µgm/mL and 2 µgm/mL respectively. #For Klebsiella pneumoniae the MIC of fosfomycin according to EUCAST interpretative criteria (S 32, R32). The MIC50 and MIC 90 of fosfomycin in Klebsiella pneumoniae was 32 µgm/mL and 1026 µgm/mL respectively. αFor Pseudomonas aeruginosa the MIC of fosfomycin according to EUCAST interpretative criteria (S 32, R32). The MIC50 and MIC 90 of fosfomycin in Pseudomonas aeruginosa was 32 µgm/mL and 1026 µgm/mL respectively. δForEnterobactersppthe MIC of fosfomycin according to EUCAST interpretative criteria (S 32, R32). The MIC50 and MIC 90 of fosfomycin in Enterobacter spp was 32 µgm/mL and 1026 µgm/mL respectively.