Table 2.
All adverse events by dose and grade*
|
Toxicity Category |
Adverse Event |
Dose Level 1 N=5 |
Dose Level 2 N=6 |
||
|---|---|---|---|---|---|
| G1 | G2 | G1 | G2 | ||
| Blood and lymphatic | Anemia | 2 | 1 | 1 | - |
| GI disorders | Nausea | - | - | 3 | - |
| Injury/procedural | Bruising | - | 1 | - | - |
| Hemorrhage | 1 | - | - | - | |
| Investigations | Creatinine increased | - | - | 1 | - |
| QTc prolonged | 2 | - | 2 | 1 | |
| Platelets decreased | - | - | 2 | 1 | |
| Metabolism | Hyperglycemia | 1 | 1 | 2 | - |
| Hyperkalemia | - | - | 1 | - | |
| Hypocalcemia | 2 | 1 | 1 | - | |
| Nervous system | Dizziness | - | - | 1 | - |
| Headache | 3 | - | 1 | 1 | |
| Psychiatric | Anxiety | 1 | - | 1 | - |
*
There were no grade 3 or 4 drug related toxicities