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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Biomaterials. 2019 Mar 21;206:13–24. doi: 10.1016/j.biomaterials.2019.03.026

Fig. 4. LProd specifically internalizes into cancer cell via iNGR-mediated cellular micropinocytosis.

Fig. 4.

(A) Schematic depiction of the mechanism how iNGR conjugation enhances tumor targeting of LProd. (B) Cellular uptake of FITC-labled LProd, PMI, LProd without iNGR and LProd with tNGR into HCT116 cells measured by flow Cytometer. (C) Statistical analysis of the results in (B) (n = 3). (D) Cellular uptake of FITC-labeled LProd, with or without free iNGR, Amiloride or Cyto D preincubation into HCT116 cells. (E) Statistical analysis of the results in (D) (n = 3). (F) Schematic diagram and measurement of the LProd internalization into noncancerous cells. (G) Cellular uptake of FITC-labled LProd and LDNc-PMI into HCT116 cells measured by flow Cytometer. (H) Statistical analysis of the results in (G) (n = 3). P values were calculated by t-test (*, p < 0.05; **, p < 0.01; ***, p < 0.001).