Table 1.
Signalplex Proteins of the Dopamine D2 Receptor In the Brain, Proteins are Grouped Based on their Function at the D2R Site. Regions of Proteins Interaction within the D2R arc Indicated. Changes in Protein/mRNA Levels for DRIPs in Post-Mortem Tissue from Schizophrenic Patients of Primates following Antipsychotic Treatment Relative to Controls (↑: Upregulatlon, ↓: Downregulation in Expression Level)
| Protein | Interaction Site | Schizophrenia (mRNA/protein) | Antipsychotic: human/monkey (mRNA/protein) | Reference |
|---|---|---|---|---|
| Receptors: | -- | -- | ||
| Dopamine, D2L/S Dopamine, D3/D1 |
-- -- |
↑ mRNA | ↑ RNA (haloperidol, clozapine) | [39] |
| Glutamate, AMPA (GluR1/2) | -- | -- | [40] | |
| Cannabinoid, CB1 | -- | -- | [41] | |
| Adenosine, A2A | -- | -- | [42] | |
| Somatostatin, SSTR5 | -- | -- | [43] | |
| Glutamale, NMDA (NR20) | 3rd cytoplasmic loop | -- | [44] | |
| Ion Channels: | ||||
| CLIC-6 | C-terminal tail | -- | [37] | |
| Kir3 | -- | -- | [45] | |
| Scaffolding, trafficking and anchoring: | ||||
| 4.1 (N/B/G/R) | 3rd cytoplasmic loop | -- | [46] | |
| Arresfin (2/3) | 2nd and 3rd cytoplasmic loop | -- | [47] | |
| Dynamin-2 | -- | -- | [48] | |
| Filamin-A | 3rd cytoplasmic loop | -- | [49] | |
| GASP | -- | -- | [50] | |
| GIPC | C-terminal tail | -- | [51] | |
| H-FABP | 3rd cytoplasmic loop | -- | [52] | |
| Calnexin | -- | -- | [53] | |
| Signaling: | ||||
| Calmodulin | 3rd cytoplasmic loop | -- | [54] | |
| NCS-1 | C-terminal tail | ↑ mRNA, protein | [26] | |
| Par-4 | 3rd cytoplasmic loop | -- | [55] | |
| Gα i/z/o | 3rd cytoplasmic loop | ↓ protein | [6] | |
| GRK2 | -- | -- | [26] | |
| RGS19 | -- | -- | [56] | |
| Spinophilin | 3rd cytoplasmic loop | ↑ mRNA | ↓ protein (haloperidol) | [57] |
| Synaptic: | ||||
| CAPS | 2nd cytoplasmic loop | -- | [46] | |
| NSF | 3rd cytoplasmic loop | -- | [40] | |
| DAT | 3rd cytoplasmic loop | -- | [58] | |