Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Spectral binding results for clotrimazole with recombinantly expressed CYP26A1, CYP26B1 or CYP2C8, suggesting enzyme inhibition occurs through type II binding interactions with the heme. Ks,unb affinity constants for CYP26A1 (13.3 nM), CYP26B1 (24.7 nM) and CYP2C8 (75.5 nM) were determined through nonlinear regression analysis (inset figures) and corrected for nonspecific binding in the in vitro assays.
