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Spectral binding properties for clotrimazole in recombinant CYP26A1, CYP26B1 and CYP2C8. Standard error values are reported for IC50, fu and Ks data.
| CYP26A1 | CYP26B1 | CYP2C8 | |
|---|---|---|---|
| IC50 (nM) | 24.7 ± 8.1 | 50.1 ± 12.1 | 725 ± 116 |
| fu (IC50 assay) | 0.661 ± 0.042 | 0.430 ± 0.031 | 0.155 ± 0.024 |
| IC50,unb (nM) | 16.3 | 21.5 | 112 |
| Ks (nM) | 533 ± 71.8 | 4954 ± 640 | 1574 ± 569 |
| fu (spectral binding assay) | 0.025 ± 0.001 | 0.005 ± 0.0006 | 0.048 ± 0.002 |
| Ks,unb (nM) | 13.3 | 24.7 | 75.5 |
| Binding Mechanism | Type II | Type II | Type II |
