Table 2.
NBL characteristics and operative outcomes based on presence or absence of IDRF at resection.
| n | IDRF negative n = 49 |
IDRF positive n = 37 |
p-value | |
|---|---|---|---|---|
| Age (months) | 86 | 19 [6, 61] | 34 [18, 48] | 0.276 |
| Body surface area (m2) | 83 | 0.52 [0.40, 0.73] | 0.62 [0.50, 0.68] | 0.088 |
| TV at diagnosis (ml) | 85 | 46.8 [16.7, 210.7] | 257.8 [136.7, 606.0] | < 0.001 |
| TV at resection (ml) | 86 | 23.9 [6.3, 63.2] | 71.3 [36.6, 220] | < 0.001 |
| COG risk stratification | ||||
| Low | 80 | 53.3% (24) | 11.4% (4) | < 0.001 |
| Intermediate | 13.3% (6) | 22.9% (8) | ||
| High | 33.3% (15) | 65.7% (23) | ||
| Stage (INSS) | ||||
| Stage 1/2 | 77 | 52.4% (22) | 17.1% (6) | 0.001 |
| Stage 3/4 | 47.6% (20) | 82.9% (29) | ||
| MYCN | ||||
| Nonamplified | 68 | 82.1% (32) | 82.8% (24) | 0.940 |
| Amplified | 18.0% (7) | 17.2% (5) | ||
| Site | ||||
| Neck | 86 | 2.0% (1) | (0) | 0.009 |
| Thoracic | 22.5% (11) | 18.9% (7) | ||
| Adrenal | 67.4% (33) | 43.2% (16) | ||
| Abdomen, nonadrenal | 4.1% (2) | 32.4% (12) | ||
| Pelvis | 4.1% (2) | 5.4% (2) | ||
| Paraneoplastic Syndrome | ||||
| Yes | 86 | 12.2% (6) | (0) | 0.027 |
| No | 87.8% (43) | 100% (37) | ||
| Resection approach | ||||
| MIS | 86 | 36.7% (18) | 2.7% (1) | < 0.001 |
| Open | 63.3% (31) | 97.3% (36) | ||
| Margins | ||||
| Negative | 73 | 46.2% (18) | 20.6% (7) | 0.022 |
| Positive | 53.9% (21) | 79.4% (27) | ||
| Estimated blood loss (ml) | 76 | 25 [10, 100] | 240 [75,450] | < 0.001 |
| Operating time (min) | 74 | 184 [133.5, 290.5] | 363.5 [279, 528] | < 0.001 |
| Length of stay (days) | 86 | 3 [2, 4] | 5 [4, 6] | < 0.001 |
| Gross total resection | ||||
| ≥ 98% resection | 79 | 80% (36) | 67.7% (23) | 0.211 |
| <98% resection | 20% (9) | 32.4% (11) | ||
| Adjacent organ resection | ||||
| No | 86 | 100% (49) | 91.9% (34) | 0.042 |
| Yes | (0) | 8.1% (3) | ||
| Intraoperative complications | ||||
| No | 86 | 93.9% (46) | 78.4% (29) | 0.033 |
| Yes | 6.1% (3) | 21.6% (8) | ||
| ICU | ||||
| No | 86 | 100% (49) | 67.6% (25) | < 0.001 |
| Yes | (0) | 32.4% (12) | ||
| Local Relapse | ||||
| No | 86 | 91.8% (45) | 89.2% (33) | 0.676 |
| Yes | 8.2% (4) | 10.8% (4) | ||
IDRF, image-defined risk factor; TV, tumor volume; COG, Children’s Oncology Group; INSS, International Neuroblastoma Staging System; MIS, minimally invasive surgery; ICU, intensive care unit.
Values are median [Q1, Q3] or % (No.)