Fig. 1.

Unlike Dex, a topical treatment of mouse skin with CpdX, CpdX-D3, or one of their enantiomers does not induce a skin epidermal atrophy. (A) H–E staining (Left) and DAPI staining for nuclei (Right) of sections of mouse ears treated as indicated (Scale bar represents 20 µm). (B) Morphometric analysis of the epidermal thickness (in µm) from H–E stained ear sections as under (A). (C) Q-RT-PCR for transcripts of kindlin-1 and REDD1 genes in mouse ears treated as indicated. Data are represented as mean ± SEM of, at least, three independent experiments with, at least, three mice per treatment.