TABLE 2.

Summary of altered proteins in STZ-induced type I diabetic hearts comparing to control: variable proteins investigated between STZ-induced diabetic rats and age-matched controls.

Protein investigated	LA	SAN	AVJ	LPF	RV
HCN4		↓
Nav1.5	↓				↓
Cav1.3		↓
Cav3.1		↓
RyR2	↓		↓	↓	↓
NCX1	↓	↓	↓	↓	↓
α-actinin				↓
Cx40				↓
Cx43	↓			↓	↓
Cx45		↓		↓	↓
NF-M	↓	↓	↓	↓	↓
β2-AR		↓	↑
Collagen I	↑	↑	↑	↑	↑
Cav3			↓	↓

↓ indicates significant decrease from control data (P < 0.05); ↑, significant increase from control data (P < 0.05). LA, left atrium; SAN, sinoatrial node; AVJ, atrioventricular junction; LPF, left Purkinje fiber; RV, right ventricle; Cav3, Caveolin 3; β₂-AR, β₂ adrenergic receptor.