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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Chem Biol Interact. 2018 Sep 17;296:45–56. doi: 10.1016/j.cbi.2018.09.001

Fig. 1. ESI-MS/MS spectra of β-estradiol and β-estradiol-S-O-glucuronide, and UGT1A1-mediated β-estradiol-O-glucuronidation in HeLa1A1 cells.

Fig. 1.

(A) ESI-MS/MS spectra of β-estradiol and β-estradiol-3-O-glucuronide in negative ion mode; (B) Excreted β-estradiol-3-O-glucuronide in extracellular solution at two concentrations of propofol (5 and 20 μM); (C) Excreted rates of β-estradiol-3-O-glucuronide at different concentrations (5 and 20 μM); Data were presented as mean ± SD. *p < 0.05, **p < 0.01 or ***p < 0.001 compared with that of β-estradiol (5 μM).