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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Chem Biol Interact. 2018 Sep 17;296:45–56. doi: 10.1016/j.cbi.2018.09.001

Fig. 11. Effects of shRNA-mediated MRP1 knock-down on the excretion of cycloicaritin-3-O-glucuronide and cellular glucuronidation.

Fig. 11.

(A) Effects of MRP1 knock-down on the excretion rates of CICT-3-G; (B) Effects of MRP1 knock-down on the intracellular levels of CICT-3-G; (C) Effects of MRP1 knock-down on the efflux clearances (CLef,app) of CICT-3-G; (D) Effects of MRP1 knock-down on cellular glucuronidation (or fmet) of CICT-3-G; CICT-3-G, cycloicaritin-3-O-glucuronide; (* Parameters of CICT-3-G in engineered HeLa1A1 cells were compared with the same parameters in control group, *p < 0.05, **p < 0.01, ***p < 0.001). All experiments were performed in triplicate (n = 3).