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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Chem Biol Interact. 2018 Sep 17;296:45–56. doi: 10.1016/j.cbi.2018.09.001

Fig. 5. Effects of Ko143 (5 and 20 μM) on the cycloicaritin-3-O-glucuronidation after incubation with cycloicaritin in HeLa1A1 cells.

Fig. 5.

(A) Effects of Ko143 on the excretion rates of CICT-3-G; (B) Effects of Ko143 on the intracellular levels of CICT-3-G; (C) Effects of Ko143 on the efflux clearances (CLef,app) of CICT-3-G; (D) Effects of Ko143 on the fraction metabolized (fmet) value of CICT-3-G. CICT-3-G, cycloicaritin-3-O-glucuronide. All experiments were performed in triplicate (n = 3). [* Parameters of CICT-3-G in Ko143 (5 and 20 μM) treated HeLa1A1 cells group were compared with the same parameters of CICT-3-G in control group, *p < 0.05, **p < 0.01, ***p < 0.001; # Parameters of CICT-3-G in Ko143 (5 μM) treated HeLa1A1 cells group were compared with the same parameters of CICT-3-G in Ko143 (20 μM) treated HeLa1A1 cells group, #p < 0.05, ##p < 0.01, ###p < 0.001].