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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Proteome Res. 2018 Apr 25;17(5):1887–1897. doi: 10.1021/acs.jproteome.7b00901

Figure 1.

Figure 1.

Effects of NME on TAA-induced liver injury after pre- and post-treatment in C57BL/6J mice. (A,B) Plasma ALT and AST activities in pretreatment status. (C) Changes of body weight during the last 24 h treatment period and (D) hepatic index (percentage of body weight) of animals in pretreatment status. (E,F) Plasma ALT and AST activities in post-treatment status. Mice were received NME after 1, 6, or 12 h of TAA administration. In TAA-treated group, ALT and AST activities in plasma and hepatic index increased significantly, and pretreatment with NME obviously inhibited the activities of the two transaminases and decreased hepatic index. Reduction in body weight was alleviated by NME. NME protected transaminases within 1 h after TAA administration. *p < 0.05 as compared with control group, **p < 0.01 as compared with control group, #p < 0.05 as compared with TAA-treated group, and ##p < 0.01 as with TAA-treated group.