Table 3. Top downregulated genes in TCQA-treated mice (vs control)*.
| Gene symbol | Gene name | Biological function | Fold-change |
P value ** |
| Ldb3 | LIM domain binding 3 | Regulator of transcription during telogen | -8.65 | 0.040 |
| Cryab | Crystallin, alpha B | Negative regulator of apoptosis | -6.89 | 0.035 |
| Ak1 | Adenylate kinase 1 | Cell cycle arrest | -6.24 | 0.027 |
| Dst | Dystonin | Cell cycle arrest | -5.34 | 0.027 |
| Gsk3b | Glycogen synthase kinase 3 beta | Phosphorylation of β-catenin | -5.08 | 0.002 |
| Tcf3 | Transcription factor 3 | Wnt/β-Catenin repression | -4.72 | 0.042 |
| Soct | Sclerostin | Negative regulation of Wnt/β-Catenin |
-4.53 | 0.013 |
| Aebp1 | AE binding protein 1 | Regulator of telogen hair follicle | -3.8 | 0.015 |
| Satb1 | Special AT-rich sequence binding protein 1 | Regulator of transcription during telogen | -3.36 | 0.026 |
| H2afv | H2A histone family | Stem cell quiescence | -3.31 | 0.040 |
| Egr1 | Early growth response 1 | Negative regulation of Wnt/β-Catenin; upregulated with aging |
-2.59 | 0.045 |
| Igfbp4 | Insulin-like growth factor binding protein 3 | Negative regulation of Wnt/β-Catenin |
-2.55 | 0.031 |
| lL-6 | Interleukin 6 | Inflammation response | -2.44 | 0.026 |
| Shisa3 | Shisa family member 3 | Negative regulator of Wnt/β-Catenin |
-2.39 | 0.002 |
| Abra | Actin-binding Rho activating protein | Regulator of transcription during telogen | -2.22 | 0.046 |
| Nfatc1 | Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 | Stem cells quiescence | -2.09 | 0.011 |
*Genes functions were obtained from Mouse Genome Informatics (MGI).
**ANOVA was performed to assess the level of significance between groups. The gene expression was considered significant when fold change was ≥ 2-fold (control vs TCQA)