a) Photographs of SPB@POM solutions with or without addition of GSH under different pH values. b) Absorption spectra of SPB@POM after incubation with 10 mM GSH for increasing time (0, 0.5, 1, 1.5, 2, 4, 6, 12 h). c) PA intensities of SPB, SPB@POM, SPB@POM incubated with 10 mM GSH and SPB@POM with 10 mM GSH at pH 6.5 (insets: schematic of PA amplification by GSH-triggered reduction of POM and low pH-induced protonation of SPB@POM). d) Temperature rise profiles and IR thermal images (insets) of SPB@POM, SPB@POM with 10 mM GSH, and SPB@POM with 10 mM GSH at pH 6.5.***P<0.001.