Extended Data Fig. 1 ∣. Quality control of the CCLE metabolomic dataset.

a, Metabolites ordered by estimated coefficients of variance (CV). b, Heatmap showing the hierarchical clustering of the CCLE metabolomic data with annotated tissues of origin. CNS: central nervous system; UAT: upper aerodigestive tract. For each metabolite (log₁₀ scale), the abundance was standardized for plotting. c, Ordered lineage effects of the 225 profiled metabolites. Each dot represents a metabolite. d, Phosphocreatine levels with medians across the CCLE cell lines grouped by tissues of origin. e, 1-methylnicotinamide levels with medians across the CCLE cell lines grouped by tissues of origin.