Table 4. Model performance for prediction of 24-hour AKI and related outcomes.
Performance of multivariable models for prediction of 24-hour AKI, sustained AKI, renal replacement therapy, and inpatient mortality, with columns signifying models utilizing different subsets of input variables. Model performance is displayed as AUC for each model when applied to data from the YNHH validation set and SRH and BH data sets.
| AUC (95% CI) | ||||||
|---|---|---|---|---|---|---|
| Full Model | Demographic | Medications | Change in Creatinine | Procedures | Laboratory Studies | |
| 24-hour AKI | ||||||
| YNHH validation set | 0.74 (0.73–0.74) | 0.65 (0.64–0.66) | 0.59 (0.59–0.60) | 0.61 (0.60–0.61) | 0.63 (0.62–0.63) | 0.69 (0.68–0.70) |
| SRH | 0.69 (0.68–0.69) | 0.62 (0.61–0.63) | 0.60 (0.59–0.61) | 0.59 (0.58–0.60) | 0.59 (0.58–0.59) | 0.64 (0.63–0.65) |
| BH | 0.76 (0.75–0.77) | 0.63 (0.62–0.65) | 0.62 (0.61–0.63) | 0.64 (0.63–0.65) | 0.60 (0.59–0.61) | 0.74 (0.73–0.75) |
| Sustained AKI | ||||||
| YNHH validation set | 0.77 (0.76–0.78) | 0.68 (0.67–0.69) | 0.62 (0.61–0.63) | 0.60 (0.59–0.61) | 0.66 (0.65–0.67) | 0.70 (0.69–0.72) |
| SRH | 0.72 (0.71–0.73) | 0.65 (0.64–0.66) | 0.62 (0.61–0.63) | 0.57 (0.56–0.58) | 0.62 (0.61–0.63) | 0.65 (0.64–0.66) |
| BH | 0.79 (0.78–0.80) | 0.65 (0.64–0.67) | 0.63 (0.62–0.65) | 0.63 (0.62–0.65) | 0.63 (0.61–0.64) | 0.76 (0.74–0.77) |
| Renal Replacement Therapy | ||||||
| YNHH validation set | 0.79 (0.73–0.85) | 0.79 (0.73–0.85) | 0.60 (0.52–0.67) | 0.51 (0.48–0.54) | 0.67 (0.61–0.74) | 0.73 (0.66–0.79) |
| SRH | 0.85 (0.80–0.89) | 0.78 (0.73–0.83) | 0.61 (0.55–0.67) | 0.51 (0.46–0.57) | 0.62 (0.55–0.69) | 0.83 (0.78–0.88) |
| BH | 0.78 (0.74–0.82) | 0.72 (0.66–0.78) | 0.56 (0.49–0.63) | 0.50 (0.47–0.54) | 0.62 (0.57–0.68) | 0.70 (0.64–0.75) |
| Inpatient Mortality | ||||||
| YNHH validation set | 0.69 (0.67–0.72) | 0.66 (0.64–0.69) | 0.59 (0.56–0.62) | 0.53 (0.51–0.54) | 0.67 (0.65–0.70) | 0.60 (0.57–0.63) |
| SRH | 0.75 (0.73–0.77) | 0.74 (0.71–0.76) | 0.67 (0.64–0.69) | 0.53 (0.52–0.55) | 0.72 (0.69–0.75) | 0.63 (0.60–0.66) |
| BH | 0.73 (0.71–0.75) | 0.68 (0.65–0.71) | 0.63 (0.60–0.66) | 0.56 (0.55–0.58) | 0.66 (0.63–0.70) | 0.65 (0.62–0.67) |
Abbreviations: AKI, acute kidney injury; AUC, area under the ROC curve; BH, Bridgeport Hospital; SRH, Saint Raphael's Hospital; YNHH, Yale New Haven Hospital.