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. 2019 Jun 6;4(11):e128886. doi: 10.1172/jci.insight.128886

Figure 6. Higher TNF levels augment diabetic albuminuria and cell death.

Figure 6

(A) Tnf expression in kidneys of wild-type and Ins2Akita mice (GSE87899) (34). (B) Tnf expression in kidneys of db/m and db/db mice (GSE87359) (35). (C) The urinary albumin-to-creatinine ratio using the urine collected from control, STZ-treated, and STZ/TNF–cotreated mice at 4, 8, and 24 hours following TNF injection. (D) Representative images of TUNEL assay of mouse kidney samples from STZ-treated and STZ/TNF–cotreated mice. (E) Quantification of positive cells per field as in D. (F) Relative transcript levels of Bcl2 and Bax in kidney samples dissected at 8 and 24 hours following TNF injection from control, STZ-treated, and STZ/TNF–cotreated mice. All data are presented as means ± SEM of 3 experiments and analyzed by 1-way ANOVA with Tukey’s post hoc test. Scale bars: 20 μm.