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. 2019 Jun 6;4(11):e127527. doi: 10.1172/jci.insight.127527

Figure 3. DOCK8-deficient memory CD4+ and CD8+ T cells exhibit signs of exhaustion, which decline after HSCT.

Figure 3

PBMCs from healthy donors (n = 17–22) and DOCK8-deficient patients either before (n = 6–7) or after (n = 16–19) HSCT were labeled with mAbs against CD4, CD8, CD45RA, CCR7, CD127, CD27, CD28, PD-1, and CD57. Coexpression of CD127 and PD-1, CD27 and CD57, and CD28 and CD57 by (A) memory CD4+ T cells (CD4+CD8–CD45RA–CCR7+/–) or (B) TEM CD8+ T cells (CD8+CD4–CD45RA–CCR7–) was determined. Contour plots are representative of 1 healthy donor and the same DOCK8-deficient patient assessed before and after HSCT. The graphs show mean ± SEM. Statistical analysis was performed with Prism using unpaired t test with Welch’s correction; *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001.