Figure 7. Elevated total and allergen-specific serum IgE levels decrease in a time-dependent manner in DOCK8-deficient patients following HSCT.
(A) Serum from healthy donors (n = 5) and DOCK8-deficient patients (n = 4–18) collected before and after HSCT was analyzed for concentrations of total IgE and IgE specific for staple foods and dust mites. (B) Data in A expressed as a percentage of pre-transplant levels of total and allergen-specific IgE for each patient and plotted against the time after HSCT. Points joined by a line are from the same patient (patients 16 and 18 in Table 1) assayed at different times after HSCT. Dotted line indicates average of healthy control values as percentage of average of patient pre-transplant values.