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. 2019 Jun 20;4(12):e126124. doi: 10.1172/jci.insight.126124

Figure 3. IFN-γ induces kidney APOL1 expression in podocytes and endothelial cells in the kidney.

Figure 3

Female APOL1 G1–transgenic mice (n = 4) were challenged with a single dose of IFN-γ (1.125 × 107 U/kg) or vehicle (PBS). FISH was used to evaluate APOL1 mRNA expression in podocytes (Nphs1), mesangial cells (Des), and endothelial cells (Pecam) in APOL1 G1 mouse kidneys 48 hours after IFN-γ challenge. Representative images shown (scale bars: 20 μm).