Skip to main content
. 2019 Jun 20;4(12):e126124. doi: 10.1172/jci.insight.126124

Figure 7. IONIS-APOL1Rx reduces APOL1 mRNA expression in kidney glomerular cells.

Figure 7

Female APOL1 G1–transgenic mice (n = 4) were treated with PBS or 50 mg/kg IONIS-APOL1Rx 1 time per week for 4 weeks and challenged with a single dose of IFN-γ (1.125 × 107 U/kg). FISH was used to evaluate APOL1 mRNA expression in podocytes (Nphs1), mesangial cells (Des), and endothelial cells (Pecam) in kidneys from IONIS-APOL1Rx– or PBS-treated APOL1 G1 mice 48 hours after IFN-γ challenge. Representative images are shown (scale bars: 20 μm).