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. 2019 Jun 6;4(11):e126910. doi: 10.1172/jci.insight.126910

Figure 2. K+-stimulated benzamil-inducible urinary Na+ loss is not due to increased Na+ delivery to ENaC, and is largely independent of MR signaling.

Figure 2

(A and B) Effect of control (A) or NaCl (B) gavage on Na+ excretion in vehicle- versus benzamil-treated mice. (C and D) Effect of control (C) or KCl (D) gavage on Na+ excretion in vehicle- versus benzamil-treated mice in the presence of MR blockade by eplerenone. As in Figure 1, differences between curves (marked with black brackets) represent benzamil-induced natriuresis (BIN). In all panels, (▲) represents vehicle- and (■) represents benzamil-treated mice. *P < 0.05 between vehicle and benzamil. $P < 0.05 between control and KCl gavage by 2-way ANOVA with Bonferroni’s multiple-comparison test. n = 8 in all presented data.