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. 2018 Jul 6;33(1):418–429. doi: 10.1096/fj.201800771R

Figure 7.

Figure 7

Aged Fabry rats develop wall thinning of the left ventricle. A) Diagram of left-ventricle (LV) echocardiographic measurements in short-axis view. Diastole indicates maximal cardiac relaxation, and systole indicates maximal cardiac contraction. B–K) Echocardiographic measurements include the following: internal dimension at diastole (LVIDd) (B), internal dimension at systole (LVIDs) (C), LV ventral-wall thickness at diastole (IVSd) (D), LV ventral-wall thickness at systole (IVSs) (E), LV dorsal-wall thickness at diastole (LVPWd) (F), LV dorsal-wall thickness at systole (LVPWs) (G), LV mass at diastole (LVd) (H), LV mass at systole (LVs) (I), fractional shortening (FS) (J), and ejection fraction (EF) (K). LV mass (H, I) was calculated using the American Society of Echocardiography estimation. Data in B–K were obtained from 4 WT and 4 KO male rats at 31 wk (7 mo) and 8 WT and 5 KO male rats at 74–77 wk (17 mo). Data were analyzed using a 2-way ANOVA, and genotype differences in echocardiography parameters were determined with Bonferroni’s multiple comparisons test. *P < 0.05, **P < 0.01.