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. 2019 Jul 11;4(13):e128351. doi: 10.1172/jci.insight.128351

Figure 6. Hyperglycemic clamp studies in chow- and HFD-fed WT and Gc-KO mice assess in vivo insulin secretory capacity.

Figure 6

(A–C) Glucose levels during hyperglycemic clamp in (A) HFD-fed or (B) chow-fed WT and Gc-KO mice, where the quantification of AUC is shown in C. (D–F) Glucose infusion rates (GIRs) during hyperglycemic clamp in (D) HFD-fed or (E) chow-fed WT and Gc-KO mice, where AUC is graphed in F. (G–I) Plasma insulin levels during hyperglycemic clamp in (G) HFD-fed or (H) chow-fed WT and Gc-KO mice, where AUC is plotted in I. n ≥ 5 mice per genotype. Data represent mean ± SEM. *P < 0.05, and **P < 0.01 by Student’s t test and ANOVA.