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. 2018 Dec 21;33(3):3420–3436. doi: 10.1096/fj.201800618RRR

Figure 1.

Figure 1

Figure 1

GEO data analysis and miRNA prediction revealed that miR-135b affects the progression of GC through the MAPK signaling pathway by targeting MST1. A–D) Thermal maps of gene expression in the 4 results of database analysis [GSE13861 (A), GSE19826 (B), GSE49051 (C), and GSE79973(D)]. The abscissa represents the sample number, the ordinate represents the name of DEGs, and the upper right histogram is the color gradation (color change from top to bottom meant value from large to small of chip expression data). In the map, each rectangle corresponds to a sample expression value, each column represents the expression of all genes in each sample, the dendrogram on the left is cluster analysis results of various genes from different samples, the top bar is the sample type, and the upper right box indicates the reference for sample color (blue for normal control samples, red for tumor samples). E) The blue part indicates the selected gene number in GSE13861, the red is selected DEGs in GSE19826, green is selected genes in GSE49051, yellow is selected DEGs in GSE79973, and the intersection of the 4 datasets is MST1. F) Expression of MST1 gene in GSE31811. The abscissa is the sample type, the ordinate is the gene name and the selected dataset name, the gray box represents the gene expression in the ineffective treatment with CDDP, the green box shows the effective treatment with CDDP, and the P value is located in the upper left corner of the map. G) Prediction results of the miRNA that mediated MST1 in the TargetScan, mirDIP, and microRNA.org databases. The intersection of the 4 groups was obtained through analysis of GC miRNA dataset GSE26595. Blue indicates the prediction results of the TargetScan database, red indicates the prediction results of the mirDIP database, green indicates the prediction results of the microRNA.org database, red corresponds to the GSE26595 database, the intersection of the 4 groups is hsa-miR-135b. H) Expression of hsa-miR-135b in GSE30070. The abscissa is the sample type, the ordinate is the gene name and the selected dataset, the gray box refers to the expression of hsa-miR-135b in the normal control group, and the green box refers to the expression of hsa-miR-135b in GC group. The difference of the miRNA expression level between the 2 samples was significant, with the P value in the upper left corner of the graph.