Figure 4. Increased plasma cytokine concentrations following GS-9620 administration.

Shown are the concentrations in plasma prior to (Pre) and at 24 hours following the indicated doses of GS-9620 for 3 cytokines that were upregulated following GS-9620 administrations. Across the samples collected immediately prior to each dose, there were no significant differences between the GS-9620–treated animals (red plots) and the control animals (blue plots). Across the samples collected at 24 hours after each dose, plasma concentrations of all 3 cytokines were significantly higher in the GS-9620–treated animals than in the vehicle controls. *P < 0.015; **P < 0.001.