Figure 2.

MMP-9 and CC chemokine secretion is higher in the dorsal air pouch exudates of CB₂^−/− mice. Dorsal air pouches of 8–10-wk-old female WT and CB₂^−/− mice were injected with 100 μg Zymosan and lavaged 2 and 6 h later for inflammatory mediator level measurement. IL-6 (A), MMP-9 (B), CCL2 (C), CCL4 (D), CXCL1 (E), CXCL2 (F), CXCL5 (G), and CXCL10 (H) levels were determined by ELISA or Luminex assays. Data are means ± sem (n = 6–14 animals/group). Statistical analysis was conducted by 2-way ANOVA with Sidak’s multiple comparisons correction. *P < 0.05.