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. 2019 Jul 11;4(13):e126241. doi: 10.1172/jci.insight.126241

Figure 12. Fecal microbial transfer from mice fed a high-salt diet predisposes recipient germ-free mice to inflammation and hypertension.

Figure 12

(A) Experimental design for fecal material transfer (FMT) from conventionally fed mice fed a high-salt diet into recipient germ-free mice. (B) Tail cuff systolic blood pressure of normal salt (NS) and high salt (HS) FMT recipient germ-free mice in response to a low subpressor dose of angiotensin II. (C and D) Plasma levels of IL-6 and IL-17 in recipient germ-free mice with FMT from high-salt diet–fed mice when compared with those with FMT from normal salt–fed mice (*P < 0.05 using 2-way repeated-measures ANOVA). (E) Paradigm illustrating how excess dietary salt alters the gut microbiome and activates DCs, leading to hypertension. A high-salt diet compromises the microbiome and induces production of IsoLG protein adduct formation in CD11c+ cells. The DCs become activated and promote T cell production of IL-17 and IFN-γ, leading to hypertension.