Gut microbiome composition in subjects with normal or high-Na+ intake based on American Heart Association recommendations of <2.3 g sodium/d during short-term and long-term intake was analyzed. (A) Relationship between sodium intake and relative abundance of bacterial taxa, including OTUs mapping to the genus Prevotella, family Ruminococcaceae, and genus Bacteroides. (B) Effect of sodium intake on the proportion of Phyla Bacteroidetes, Firmicutes, and Proteobacteria (*P < 0.05, **P < 0.001 using 2-tailed unpaired Student’s t tests).