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. 2019 Jul 11;4(13):e126467. doi: 10.1172/jci.insight.126467

Figure 4. Bone BMP2 expression by RT-PCR and serum BMP2 levels.

Figure 4

BMP2 mRNA expression in bone (A). Total RNA was extracted from bone marrow–flushed femurs 13 weeks of age and mRNA levels of BMP2 were determined by RT-PCR. Data are expressed as mean ± SEM, of 3–6 determinations normalized to Gapdh mRNA. ◊◊◊◊P ≤ 0.0001, ◊P ≤ 0.05 compared with WT mice not treated with adenine or to mice of the same genotype on a non-adenine–containing diet *P ≤ 0.05, determined by ANOVA with Bonferroni adjustment. Serum BMP2 levels at 13 weeks of age in mice of the indicated genotype (B). Data are expressed as mean ± SEM, (n = 3–6 mice of each genotype) compared with mice of the same genotype on a non-adenine–containing diet *P ≤ 0.01 or compared to Wt mice ◊◊◊◊P ≤ 0.0001, ◊P ≤ 0.05 by ANOVA with Bonferroni adjustment