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. 2019 Jun 5;132(11):1344–1353. doi: 10.1097/CM9.0000000000000232

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Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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NBP decreased BBB disruption and upregulated the expression of TJ proteins. (A) Evans blue dye leakage (n = 6). (B) Representative immunohistochemistry staining graphs of claudin-5, ZO-1, and occludin (original magnification, ×400). (C) Western blotting images. (D, E, F) Densitometric analysis of protein bands (n = 6). β-actin served as the loading control. ^∗P < 0.01 vs. the sham group; ^†P < 0.05 vs. the model group; ^‡P < 0.01 vs. the model group; ^§P < 0.05 vs. the NBP-M group. BBB: Blood-brain barrier; NBP: DL-3-n-butylphthalide; TJ: Tight junction; ZO-1: Zonula occludens-1.